BP-554
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This article, BP-554, was written by RelentlessRecusant. Please do not edit this fiction without the writer's permission. |
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BP-554, otherwise known as BP 554, IUPAC name 1-[3-(3,4-Methylenedioxyphenoxy)propyl]-4-phenyl-piperazine, is a selective chemical agonist of the 5-HT1A receptor.[1]
By competitive radioligand binding assay, BP-554 has a Ki = 4.7 nM for binding at the 5-HT1A receptor, with substantial selectivity in vitro (several orders of magnitude) versus a variety of other receptors, including 5-HT1 receptors and 5-HT2 receptors.
Serotoninergic transmission selectively mediated through the 5-HT1A receptor has previously shown to be tightly linked to aggression; selective antagonism of 5-HT1A has been shown to reduce aggression.[2] Thus, BP-554 is a potent stimulant of hyperactivity and aggression in humans.
It was originally synthesized and characterized by Matsuda et. al in 1989 at Osaka University and Mitsubishi Kasei Co. at Japan.
[edit] References
- ↑ Matsuda et. al (1989). Agonist activity of a novel compound, 1-[3-(3,4-methylenedioxyphenoxy) propyl]-4-phenyl piperazine (BP-554), at central 5-HTIA receptors. European Journal of Pharmacology (170): 75-82.
- ↑ Nelson and Trainor (2007). Neural mechanisms of aggression. Nature Reviews Neuroscience (8): 536-546.
| Chemical Biology: Small-Molecule Control of Biological Systems (RelentlessRecusant) | ||
|---|---|---|
| | ||
| Receptor Tyrosine Kinases | A-83-01 (TGFβ/Activin) · BPIQ-II (EGFR) · Dorsomorphin/LDN-193189 (TGFβ/BMP) · SU5402 (FGFR) | |
| Signaling Kinases | A-769662 (AMPK) · BMS-354825 (BCR-ABL, Src)· BIO-Acetoxime (GSK3) · CHIR99021 (GSK3) · GO 6976 (PKC) · IMD-0354 (IκBa) · PD184352 (MAPK) · SB203580 (MAPK) · Y-27632 (ROCK) | |
| G Protein-Coupled Receptor | (+)-WIN-55212 (CB1/CB2) · ±-Sulpride (D2) · A 841720 (mGluR1) · BP-554 (5-HT1A) · Hh-Ag1.5 (Smo) · Cyclopamine/KAAD-Cyclopamine (Smo) · SANT1 (Smo) · SB-277011 (D3) | |
| Ion Channels | BAY K8644 (Cav1.2) · Bicuculline (GABAAR) · Cymarin (Na+/H+) · G-strophanthin (Na+/H+) · L-AP4 (Na+/H+) · Oxcarbazepine (Na+) · Resiniferatoxin (TRPV1) · Sarmentogenin (Na+/H+) · Theanine (AMPAR, NMDAR) | |
| Transporters | O-1783 (DAT) · WF-23 (DAT, SERT) | |
| Nuclear Receptor | All-trans retinoic acid (RAR/RXR) · GW501516 (PPARδ) · RU-486 (Nr3c1, Nr3c3) | |
| Protein Phosphatases | Endothall (PP2A) | |
| Polypharmacological | Phosphoserine (mGluR4) · PK115-584 (Tcf4/β-catenin, PKC) · Pluripotin · Reversine | |
| Other | 2C-E (DAT) · 4-methoxyphenyl-HTI-286 (α/β-tubulin) · Compound E/DAPT (presenilin-1) · D-cysteine · D-phenylalanine · Flurbiprofen (COX) · JZL184 (MAGL) · QS11 (RAFGAP1) · RO-28-1675 (glucokinase) · Robotnikinin (Shh) · Selegiline (MAOB) | |
| Uncharacterized | Neuropathiazol | |
| Libraries | Kinase Inhibitor Library | |
| Publications | ||
| Small molecule-mediated manipulation of the adult human induces selective and reversible control of physiological and psychological phenotype (Rubin et. al, 2590. Nature Medicine) | ||
| Source · Edit | ||
