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BP-554

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40px-Terminal.png This article, BP-554, was written by RelentlessRecusant. Please do not edit this fiction without the writer's permission.
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BP-554

The chemical structure of BP-554.

BP-554, otherwise known as BP 554, IUPAC name 1-[3-(3,4-Methylenedioxyphenoxy)propyl]-4-phenyl-piperazine, is a selective chemical agonist of the 5-HT1A receptor.[1]

By competitive radioligand binding assay, BP-554 has a Ki = 4.7 nM for binding at the 5-HT1A receptor, with substantial selectivity in vitro (several orders of magnitude) versus a variety of other receptors, including 5-HT1 receptors and 5-HT2 receptors.

Serotoninergic transmission selectively mediated through the 5-HT1A receptor has previously shown to be tightly linked to aggression; selective antagonism of 5-HT1A has been shown to reduce aggression.[2] Thus, BP-554 is a potent stimulant of hyperactivity and aggression in humans.

It was originally synthesized and characterized by Matsuda et al. in 1989 at Osaka University and Mitsubishi Kasei Co. at Japan.

References

  1. Matsuda et. al (1989). Agonist activity of a novel compound, 1-[3-(3,4-methylenedioxyphenoxy) propyl]-4-phenyl piperazine (BP-554), at central 5-HTIA receptors. European Journal of Pharmacology (170): 75-82.
  2. Nelson and Trainor (2007). Neural mechanisms of aggression. Nature Reviews Neuroscience (8): 536-546.



Chemical Biology: Small-Molecule Control of Biological Systems (RelentlessRecusant)
Compound Names (Biological Targets)
Receptor Tyrosine Kinases A-83-01 (TGFβ/Activin) · BPIQ-II (EGFR) · Dorsomorphin/LDN-193189 (TGFβ/BMP) · SU5402 (FGFR)
Signaling Kinases A-769662 (AMPK) · BMS-354825 (BCR-ABL, Src)· BIO-Acetoxime (GSK3) · CHIR99021 (GSK3) · GO 6976 (PKC) · IMD-0354 (IκBa) · PD184352 (MAPK) · SB203580 (MAPK) · Y-27632 (ROCK)
G Protein-Coupled Receptor (R)-(+)-WIN 55212 (CB1/CB2) · ±-Sulpride (D2) · A 841720 (mGluR1) · BP-554 (5-HT1A) · Hh-Ag1.5 (Smo) · Cyclopamine/KAAD-Cyclopamine (Smo) · SANT1 (Smo) · SB-277011 (D3)
Ion Channels BAY K8644 (Cav1.2) · Bicuculline (GABAAR) · Cymarin (Na+/H+) · G-strophanthin (Na+/H+) · L-AP4 (Na+/H+) · Oxcarbazepine (Na+) · Resiniferatoxin (TRPV1) · Sarmentogenin (Na+/H+) · Theanine (AMPAR, NMDAR)
Transporters O-1783 (DAT) · WF-23 (DAT, SERT)
Nuclear Receptor All-trans retinoic acid (RAR/RXR) · GW501516 (PPARδ) · RU-486 (Nr3c1, Nr3c3)
Protein Phosphatases Endothall (PP2A)
Polypharmacological Phosphoserine (mGluR4) · PK115-584 (Tcf4/β-catenin, PKC) · Pluripotin · Reversine
Other 2C-E (DAT) · 4-methoxyphenyl-HTI-286 (α/β-tubulin) · Compound E/DAPT (presenilin-1) · D-cysteine · D-phenylalanine · Flurbiprofen (COX) · JZL184 (MAGL) · QS11 (RAFGAP1) · RO-28-1675 (glucokinase) · Robotnikinin (Shh) · Selegiline (MAOB)
Uncharacterized Neuropathiazol
Libraries Kinase Inhibitor Library
Publications
Small molecule-mediated manipulation of the adult human induces selective and reversible control of physiological and psychological phenotype (Rubin et. al, 2590. Nature Medicine)
Source · Edit

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