Cyclogenol
From the Halo Fan Fiction Wikia, writing 12,597 fan fiction articles
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This article, Cyclogenol, was written by RelentlessRecusant. Please do not edit this fiction without the writer's permission. |
Cyclogenol ("AS 163498") is a small-molecule chemical inhibitor of CDKN1B (p27Kip1). It was originally synthesized and characterized by the Department of Heuristic Biology at Acumen Science Laboratories, and in the Acumen internal chemical collection, is referenced as "EP 163498".
It has been previously shown that abrogation of p27Kip1 in mice induces global cellular hyperplasia by increases in organ cellular density and increased mean body and organ size[1] and that even haploinsufficiency of p27Kip1 leads to removal of its tumor suppressor activity.[2]
[edit] References
- ↑ Fero et. al (1996). A Syndrome of Multiorgan Hyperplasia with Features of Gigantism, Tumorigenesis, and Female Sterility in p27Kip1-Deficient Mice. Cell (85): 733-744.
- ↑ Fero et. al (1998). The murine gene p27Kip1 is haplo-insufficient for tumour suppression. Nature (396): 177-180.
[edit] Behind the Scenes
- While cyclogenol is a fictitious inhibitor of CDKN1B, the biological activities of CDKN1B described are indeed real-world, and Fero et. al (1996) and Fero et. al (1998) are real world publications in Cell and Nature, respectively.
