|This article, UNSC Ether-à-go-go, was written by RelentlessRecusant. Please do not edit this fiction without the writer's permission.|
The UNSC Ether-à-go-go is a vessel of the UNSC Office of Naval Intelligence.
Behind the ScenesEdit
It is named after ether-a-go-go, a murine gene that encodes a protein formally known as "potassium voltage-gated channel, subfamily H (eag-related), member 1" (KCNH1). In humans, the homologue is known as "potassium voltage-gated channel, subfamily H (eag-related), member 1" (KCNH2), and is otherwise known as human ether-a-go-go related gene (hERG). hERG is an important target for discovery toxicology in pharmaceutical development of lead and hit small-molecule chemical compounds for drug discovery because its blockade is a common non-specific side effect of many pharmacological agents, and its blockade induces prolongation of the QT cardiac arrhythmia and may induce fatal cardiac tachyarrythmia (Torsades de Pointe).
- ↑ Kramer et. al (2007). The application of discovery toxicology and pathology towards the design of safer pharmaceutical lead candidates. Nature Reviews Drug Discovery (6): 636-649.