WF-23
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This article, WF-23, was written by RelentlessRecusant. Please do not edit this fiction without the writer's permission. |
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WF-23, IUPAC name 1-((1S,2S,3R,5S)-8-methyl-3-(naphthalen-2-yl)-8-azabicyclo[3.2.1]octan-2-yl)propan-1-one, is a dopamine reuptake inhibitor that has an IC50 of 0.12 nM for the dopamine transporter and an IC50 of 0.39 nM for the serotonin transporter, with binding affinities of 1400 and 770 times over cocaine, respectively, for the former and latter transporters[1].
It was extensively characterized by Daunais et. al in 1998 at the Wake Forest University School of Medicine at North Carolina at North Carolina, United States of America.
[edit] References
- ↑ Daunais et. al (1998). Long-Acting Blockade of Biogenic Amine Transporters in Rat Brain by Administration of the Potent Novel Tropane 2β-Propanoyl-3β-(2-Naphthyl)-Tropane. The Journal of Pharmacology and Novel Therapeutics (285):1246–1254.
| UNSC Drugs for Interrogation and Torture: Small Molecule Modulators of Psychology and Perception | ||
|---|---|---|
| A 841720 (mGluR1) · L-741,626 (D2) · Salvinorin A (κ-opioid) · WF-23 (DAT, SERT) | ||
| Source · Edit | ||
| Chemical Biology: Small-Molecule Control of Biological Systems (RelentlessRecusant) | ||
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| | ||
| Receptor Tyrosine Kinases | A-83-01 (TGFβ/Activin) · BPIQ-II (EGFR) · Dorsomorphin/LDN-193189 (TGFβ/BMP) · SU5402 (FGFR) | |
| Signaling Kinases | A-769662 (AMPK) · BMS-354825 (BCR-ABL, Src)· BIO-Acetoxime (GSK3) · CHIR99021 (GSK3) · GO 6976 (PKC) · IMD-0354 (IκBa) · PD184352 (MAPK) · SB203580 (MAPK) · Y-27632 (ROCK) | |
| G Protein-Coupled Receptor | (+)-WIN-55212 (CB1/CB2) · ±-Sulpride (D2) · A 841720 (mGluR1) · BP-554 (5-HT1A) · Hh-Ag1.5 (Smo) · Cyclopamine/KAAD-Cyclopamine (Smo) · SANT1 (Smo) · SB-277011 (D3) | |
| Ion Channels | BAY K8644 (Cav1.2) · Bicuculline (GABAAR) · Cymarin (Na+/H+) · G-strophanthin (Na+/H+) · L-AP4 (Na+/H+) · Oxcarbazepine (Na+) · Resiniferatoxin (TRPV1) · Sarmentogenin (Na+/H+) · Theanine (AMPAR, NMDAR) | |
| Transporters | O-1783 (DAT) · WF-23 (DAT, SERT) | |
| Nuclear Receptor | All-trans retinoic acid (RAR/RXR) · GW501516 (PPARδ) · RU-486 (Nr3c1, Nr3c3) | |
| Protein Phosphatases | Endothall (PP2A) | |
| Polypharmacological | Phosphoserine (mGluR4) · PK115-584 (Tcf4/β-catenin, PKC) · Pluripotin · Reversine | |
| Other | 2C-E (DAT) · 4-methoxyphenyl-HTI-286 (α/β-tubulin) · Compound E/DAPT (presenilin-1) · D-cysteine · D-phenylalanine · Flurbiprofen (COX) · JZL184 (MAGL) · QS11 (RAFGAP1) · RO-28-1675 (glucokinase) · Robotnikinin (Shh) · Selegiline (MAOB) | |
| Uncharacterized | Neuropathiazol | |
| Libraries | Kinase Inhibitor Library | |
| Publications | ||
| Small molecule-mediated manipulation of the adult human induces selective and reversible control of physiological and psychological phenotype (Rubin et. al, 2590. Nature Medicine) | ||
| Source · Edit | ||
